September 2014 Critical Care Case of the Month: Bad Case of Colic

Sherry Andrews MD

Eyad Almasri MD

Pulmonary and Critical Care

UCSF Fresno

Fresno, CA

History of Present Illness:

A 70 year old man with a past medical history of chronic kidney disease, bipolar disorder, benign prostatic hypertrophy, hypertension and diabetes presented to the emergency department with constipation associated with bloating for 15 days. He denies flatus. He tried over the counter laxatives (polyethylene glycol) with no relief. He has no recent history of colonoscopy or recent antibiotic use. He denies chills, diarrhea, dysuria, fever, hematochezia, hematuria, melena, nausea or vomiting. In the emergency department, he is tachypneic with a grossly distended abdomen.

Past Medical History:

• Diabetes
• Hypertension
• Chronic kidney disease
• Bipolar disorder
• Benign prostatic hypertrophy
• Hyperlipidemia

Past Surgical History:

• Cholecystectomy 2012

Medications:

• Aspirin 81 mg daily
• Furosemide 20 mg daily
• Quetiapine 300 daily
• Doxazosin- 4 mg daily
• Clonazepam 1 mg – twice daily as needed
• Simvastatin 20 mg – daily
• Pioglitazone 15 mg daily

Social History:

He is a retired farm laborer and worked in a cannery. He is married and has two adult children.

He was a former smoker and quit in 2010 He denies any alcohol or illicit drug use

Physical Exam:

• Vital signs – Temperature 37.2 °C, heart rate 84 beats/min, respiratory rate 18-24 breaths/min, blood pressure 121/83 mmHg, SpO2 94 % on 4 L NC 
• General – Average build, well-nourished, in mild distress
• HEENT – Unremarkable
• Neck - Supple, no jugular venous distention
• Chest – Decreased breath sounds right base more than left base
• Heart - Regular rate, normal S1/S2, no murmur
• Abdomen – hypoactive bowel sounds, soft, distended, non-tender to palpation but diffusely tympanic.
• Neurological - Appropriately moves all 4 extremities, CN II-XII grossly intact
• Extremities - No edema
• Skin - No rash or palpable nodules

Laboratory:

• CBC: WBC 6.4 X 10³ /μL, hemoglobin 15.3 g/dL, hematocrit 45%, Platelets 121,000 /μL.
• Chemistries: Na⁺ 141 mmol/L, K⁺ 4.5 mmol /L, Cl^- 105 mmol /L, CO₂ 25 mmol /L, blood urea nitrogen (BUN) 24 mg/dL, creatinine 1.2 mg/dL, glucose 95 mg/dL, calcium 9.9 mg/dL, albumin 4.2 g/dL, liver function tests within normal limits. hemoglobin A1C 5.1%. lactic acid 1.8 mmol/L
•  Coagulation: Prothrombin time (PT) 16.6 sec, international normalized ratio (INR) 1.3

Radiography:

A CT scan abdomen and pelvis was done and a representative coronal view is shown in Figure 1.

Panel 1. Coronal cut of computed Tomography (CT) of the abdomen and pelvis on admission.

Which of the following are characteristics of acute colonic pseudo-obstruction (Ogilvie’s syndrome)? (Click on the correct answer to proceed to the next panel)

1. Antibiotics and abnormal bacterial overgrowth are implicated in the pathogenesis
2. Immediate surgical decompression is required
3. It is a complication of inflammatory bowel disease
4. It occurs in the absence of an anatomic lesion that obstructs the flow of intestinal contents

Reference as: Andrews S, Almasri E. September 2014 critical care case of the month: bad case of colic. Southwest J Pulm Crit Care. 2014;9(3):151-9. doi: http://dx.doi.org/10.13175/swjpcc094-14 PDF 

August 2014 Critical Care Case of the Month: The Beans Are Done

Theodore Loftsgard RN, CNP

Zanele Manaka R.R.T., C.R.T.

Jocelyn Coy R.N.

Jared J. Jones, Pharm.D., R.Ph.

Division of Critical Care

Mayo Clinic

Rochester, Minnesota

Case Presentation

A 68-year-old woman was admitted to the ICU due to acute renal failure in setting of ovarian cancer recurrence.

She reports a two week history of abdominal pain with increased, loose ileostomy output, nausea, one episode of vomiting of food returns, and profound increasing generalized weakness. She states she has been voiding urine in normal frequency. She took her most recent dose of Xarelto 20mg the evening prior to presentation.

On ICU arrival, she was alert and oriented but pale and underweight with dry mucous membranes. She reported 2/10 generalized abdominal pain. Her blood pressure was stable. 

PMH

March 2013: Diagnosed with stage IIIC metastatic ovarian cancer.  She underwent extensive abdominal surgery including radical hysterectomy, diverting loop ileostomy and cholecystectomy.  Final pathology: grade 3 serous carcinoma involving omentum, descending colon, cecum and terminal ileum, both ovaries with implants on bilateral tubes and uterine serosa, right pelvic side wall, right diaphragm, 3 right paraaortic lymph nodes, and gallbladder. 

April 2013: She developed thrombus of the bilateral peroneal veins, left posterior tibial vein, and right soleal veins and was started on Lovenox She was recently transitioned to rivaroxaban (Xarelto).

February 2014: abdominal ultrasound showed numerous small, hypoechoic nodules and lesions throughout the liver which were worrisome for metastatic disease. She presented to the clinic today for a second opinion.

Current Medications

1. Fentanyl 100 mcg/hr patch 72 hour 1 patch transdermally every 3 days
2. Ibuprofen PRN
3. Oxycodone PRN
4. Rivaroxaban (Xarleto®) 20 mg daily
5. Sertraline (Zoloft®) 25 mg daily

Past Medical/Surgical History

    Past Medical History   

1. Craniocervical dystonia receives Botox injections.
2. Ovarian cancer

    Past Surgical History  

1. Appendectomy at 8 years old.
2. Tonsillectomy.
3. Laparoscopy in 1983 for infected Dalkon Shield.
4. L5 bulging disk surgery in the 1990s.
5. Total abdominal hysterectomy, bilateral salpingo-oophorectomies, cholecystectomy, lymphadenectomy, and tumor debulking for ovarian cancer March 2013.

Physical Exam

Vital signs: height 164.3 cm, weight 42.90 kg, BSA(G) 1.40 M², BMI 15.892 Kg/M², temperature 36.4 °C, respiratory rate 13 breaths/minute, blood pressure 148/77 mmHg.  pulse 64/minute.  SpO2 98% on room air.

Heart: S1, S2 with no murmur, click, rub. Sinus rhythm, rate 64, no ectopy.

Lungs: Respirations symmetrical and easy with bilateral breath sounds clear to auscultation.

Abdomen: Slightly firm, nondistended, mild tenderness to palpation, bowel sounds present. Ostomy pink with dark brown liquid output in bag.

Electrocardiogram

Figure 1. ICU admission electrocardiogram.

Ultrasonography

Figure 2. Panel A: Static image from abdominal ultrasound of inferior vena cava. Panel B: Static image from abdominal ultrasound showing longitudinal axis of left kidney. Panel C: Static image from abdominal ultrasound showing longitudinal axis of right kidney. Lower panel: movie of ultrasound of inferior vena cava.

Which of the following is (are) true? (Click on the correct answer to proceed to the next panel)

1. The electrocardiogram shows tall, peaked T waves
2. The inferior vena cava is collapsed suggesting volume depletion
3. There is hydronephrosis of the left kidney
4. There is hydronephrosis of the right kidney
5. All of the above

Reference as: Loftsgard TO, Manaka Z, Coy J, Jones JJ. August 2014 critical care case of the month: the beans are done. Southwest J Pulm Crit Care. 2014;9(2):72-82. doi: http://dx.doi.org/10.13175/swjpcc087-14 PDF

May 2014 Critical Care Case of the Month: Second Wind

Kenneth K. Sakata, MD

Sudheer Penupolu, MD 

Robert W. Viggiano, MD

Department of Pulmonary Medicine

Mayo Clinic Arizona

Scottsdale, AZ

History of Present Illness

A 65 year old woman was admitted for gastrointestinal bleeding as evidence by hematochezia. At the time of admission she denied any respiratory symptoms other than mild dyspnea. However, she rapidly developed respiratory failure, was transferred to the ICU and required emergent intubation.

PMH, FH, SH

She has a history of rheumatoid arthritis with a cervical spine fusion. There is also a history of sarcoidosis and she was receiving prednisone 30 daily up until the time of admission. There is no significant family history. She does not smoke or drink.

Physical Examination

Afebrile. Pulse 78. BP 105/65 mm Hg. Respirations: 28. SpO2 96% while receiving an FiO2 of 60% at the time of transfer to the ICU.

Neck: No jugular venous distention.

Lungs: Scattered rales and rhonchi.

Cardiovascular: Regular rhythm. 

Abdomen: no hepatosplenomegaly.

Radiography

A portable chest x-ray taken after intubation is shown in figure 1.

Figure 1. Portable chest x-ray taken shortly after intubation.

Which of the following best describe the chest x-ray? (Click on the correct answer to move to the next panel)

1. Chronic interstitial disease
2. Diffuse consolidation
3. Endotracheal tube in the right mainstem bronchus
4. Small right pneumothorax
5. All of the above

Reference as: Sakata KK, Penupolu S, Viggiano RW. May 2014 critical care case of the month: second wind. Southwest J Pulm Crit Care. 2014;8(5):258-65. doi: http://dx.doi.org/10.13175/swjpcc033-14 PDF

April 2014 Critical Care Case of the Month: Too Much, Too Fast

Kenneth Sakata, MD

Richard A. Helmers, MD

Department of Pulmonary Medicine

Mayo Clinic Arizona

Scottsdale, AZ

History of Present Illness

A 69 year old man was admitted to the intensive care unit with shortness of breath and atrial fibrillation with a rapid ventricular response.

PMH, FH, SH

He has a history of peripheral vascular disease, end-stage renal disease and is receiving chronic hemodialysis.

Physical Examination

Afebrile. Pulse 135 and irregular. BP 105/65 mm Hg. SpO2 96% while receiving oxygen at 2L/min by nasal cannula.

HEENT: Unremarkable.

Neck: Jugular venous distention to the angle of the jaw while the head is elevated at 45 degrees.

Lungs: Decreased breath sounds at the right base.

Cardiovascular: Irregularly, irregular rhythm. 2-3+ pretibial edema.

Abdomen: no hepatosplenomegaly.

Radiography

The admission chest x-ray is shown in figure 1.

Figure 1. Admission portable chest x-ray.

Which of the following is the best interpretation of the chest x-ray given the clinical situation? (Click on the correct answer to move to the next panel)

1. Hepatomegaly elevating the right diaphragm
2. Large right pleural effusion
3. Paralyzed right diaphragm
4. Right lower lobe pneumonia
5. Right middle lobe pneumonia

Reference as: Sakata K, Helmers RA. April 2014 critical care case of the month: too much, too fast. Southwest J Pulm Crit Care. 2014;8(4):205-12. doi: http://dx.doi.org/10.13175/swjpcc031-14 PDF

December 2013 Critical Care Case of the Month: I Don’t Have a Drinking Problem

Robert Raschke MD

Elijah Poulos MD

Adam Bosak MD

Critical Care Medicine

Banner Good Samaritan Medical Center

Phoenix, AZ

History of Present Illness

A 69-year-old male retired diabetic police officer was admitted to the ICU with intractable vomiting, severe abdominal pain and acute blindness. About a week prior, he suffered urinary frequency and was prescribed ciprofloxacin at urgent care with a presumptive diagnosis of urinary tract infection.  Over the course of the week his urinary frequency resolved and he became anuric, he developed progressively worsening nausea and eventually vomiting to the point that he was unable to keep anything down, and severe bilateral lower abdominal and pelvic pain.    His wife and son actually forced him into the ER when he became blind the day of admission. He denied fever, dysuria, cough and headache.   In our emergency room he was noted to be in moderate distress with tachycardia, tachypnea, hyperpnoea and completely blind in both eyes unable to discern even simple shadows.

PMH, SH, FH

The patient is a retired police officer with a past medical history of diabetes mellitus and benign prostatic hypertrophy.  The patient denied alcohol, tobacco, or illicit drug use. He works out at a local gym almost daily since being diagnosed with diabetes a couple of years ago.

Medications

• Glipizide
• Metformin
• Tamsulosin

Physical Exam

Blood pressure160/95 mmHg with a heart rate of 110, respiratory rate 35, SpO2 99% on 2 lpm nasal cannula, and temp 36.0° C.  He appeared uncomfortable and moderately distressed, lethargic but arousable with GCS 13. He was able to briefly answer simple questions. His eyes were conjugate, but did not track nor fix on objects placed in front of his eyes, and he could vaguely discern the light of a bright flashlight shined into both eyes. His pupils were 3-4 mm and fixed, with no light reflex elicitable, even with magnified examination of the pupil using an ophthalmoscope.  On fundoscopic exam his discs were flat, and there were no hemorrhages or other lesions seen.  He was tachycardic but regular with normal heart tones, and a bedside echocardiogram showed good left ventricular function.  He had Kussmaul breathing with an odor of ketones and clear lungs. The lower abdomen was distended and tender, and a Foley catheter insertion returned 2 liters of yellow urine which resolved his abdominal pains.  He had no peripheral edema and his hands were cool.  The rest of his physical examination was unremarkable.

Laboratory Evaluation

Initial laboratory evaluation included a white blood count 24.3 K/mm3 with 79% segmented neutrophils and no bands, hemoglobin 14.7 g/dL; sodium 138 mmol/L;  potassium 5.1 mmol/L; chloride 92 mmol/L; and CO₂ 4 mmol/L, yielding an anion gap of 44 when corrected.  His BUN was 116 mg/dL; creatinine of 7.7 mg/dL.  A venous blood gas showed a pH 6.77 pCO₂ 17 mmHg; pO₂ 73 mmHg; bicarbonate of 3 mmol/L. Urinalysis showed negative leukocyte esterase, 1-5 leukocytes per HPF, glycosuria and ketonuria.

Radiology Evaluation

Admission chest x-ray is in Figure 1. 

Figure 1. Admitting chest radiograph.

Computerized tomography of the abdomen showed no urinary tract obstruction (was performed after the Foley catheter was placed) and no other significant findings. Piperacillin/tazobactam and gentamicin were started for possible urinary tract infection with sepsis.

Which of the following is the best fits the clinical presentation explaining both his metabolic abnormalities and blindness? (click on correct answer to move to next panel)

1. Acute renal failure
2. Alcoholic ketoacidosis
3. Diabetic ketoacidosis
4. Ethylene glycol ingestion
5. Methanol ingestion

Reference as: Raschke RA, Poulos E, Bosak A. December 2013 critical care case of the month: I don't have a drinking problem. Southwest J Pulm Crit Care. 2013;7(6):328-35. doi: http://dx.doi.org/10.13175/swjpcc141-13 PDF

July 2013 Critical Care Case of the Month: The Fortuitous Critical Care Consult

Clement U. Singarajah, M.D.

Elijah Poulos, M.D.

Phoenix VA Medical Center

Phoenix, AZ

History of Present Illness

A 70 year old male with squamous cell cancer of the hypopharynx had undergone a laser ablation and debridement as an outpatient. The ENT surgeon placed a # 6 Shiley DCT tracheostomy tube and the patient did well after the procedure. His chest x-ray after the procedure revealed right lower lobe atelectasis but was interpreted as otherwise normal (Figure 1).

Figure 1. Portable chest-ray after laser ablation and tracheostomy placement.

Due to aspiration and feeding issues, he was scheduled 2 weeks later for percutaneous endoscopic gastrostomy (PEG) tube placement as an outpatient. However, the gastroenterologist cancelled the procedure due to copious secretions from tracheal site, described as purulent and some mild respiratory distress. He was admitted to the general medicine service at the Phoenix VA Medical Center.  

Physical Examination

On examination of the patient, was non-toxic, talking, and alert. Vital signs were within normal limits, but with he had mild dyspnea and moderately thick secretions. A tracheostomy tube was in place in the neck. There were no areas of tenderness over his neck. The remainder of his physical examination was normal.

Radiography

A chest x-ray was performed (Figure 2). 

  

Figure 2. Admission PA (Panel A) and lateral (Panel B) chest x-ray.

Which of the follow are abnormal findings of the chest radiography?

1. The distal tip of the tracheostomy tube is not aligned with the tracheal stripe
2. There is a right pleural effusion
3. There is an air-fluid level in the right lower lung
4. There is right lower lobe atelectasis and/or consolidation
5. All of the above 

Reference as: Singarajah CU, Poulos E. July 2013 critical care case of the month: the fortuitous critical care consult. Southwest J Pulm Crit Care. 2013;7(1):10-16. doi: http://dx.doi.org/10.13175/swpcc075-13 PDF